DotNetNuke has a new ability to show PopUp's much more easily!  You can make entire modules work in a single popup or extend module functionality and usability.

For a long time I have always used the Globals.NavigateUrl() method in DotNetNuke to create links in my custom modules.  I have recently converted to using the FriendlyUrl provider in DotNetNuke.  The big advantage for me was to create a custom page url for SEO purposes without hacking the DNN framework.  I wanted to get rid of the standard Default.aspx and also create urls that were more SEO friendly.